The Society of Toxicology Contemporary Concepts in Toxicology (SOT CCT) conference on Toxicoepigenetics: The Interface of Epigenetics and Risk Assessment will be held November 2–4, 2016, in Tysons, Virginia. The epigenome is a dynamic regulatory framework that controls the use of genomic information to govern the response of cells, tissues, organs, and individuals to their environment. As a master regulator of gene expression, the epigenome is responsive to a diverse range of environmental factors including toxicant exposure, diet, stress, and socioeconomic circumstances. Traditional toxicological paradigms have relied on factors such as age, genetic polymorphisms, and disease status to identify variability in responsiveness to environmental toxicant exposure; however, these factors are neither sufficient to faithfully identify differentially responsive individuals, nor are they modifiable factors that can be leveraged to mitigate adverse health effects of toxicant exposures. An individual’s epigenome, on the other hand, is malleable and shaped by interactions with chemical and non-chemical aspects of the environment, giving it potential as a tool for the promotion of public health. The field of toxicoepigenetics is rapidly evolving to provide novel insights into the mechanisms underlying exposure related susceptibility and disease; however, the utility and practicality of using epigenetic data in public health and risk assessment remains unclear. The “state of the science” will be examined to identify potential applications and predictable limitations facing the integration of epigenetic data into human health risk assessment paradigms. This conference will begin by presenting cutting-edge research on the role of the epigenome as a central mechanism linking environmental exposures to adverse health outcomes, followed by presentations and discussion outlining models for the use of epigenetic and epigenomic data from mechanistic studies and identifying current perspectives on the incorporation of epigenetic data into future risk assessment paradigms.
As a participating member of the Scientific Liaison Coalition (SLC), Members of SPS receive discounted registration rates for this Meeting.
For more information, to submit an abstract, and to register, please visit the conference website.