NC3Rs FOB Survey: Invitation to contribute by July 13


The FOB/Irwin tests are standard methods for investigating safety signals during the development of pharmaceuticals. However, there is little information on how the tests are carried out and how the data generated is used to inform decision making. In collaboration with an international Expert Working Group, the National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) is conducting a survey to gather information on how the tests and data are used.

We would like to receive responses from those who generate, work with or make decisions based on data from the FOB/Irwin tests in any species, as stand-alone studies or integrated within other (e.g. toxicology) studies. We welcome responses from those working in drug development, those working for contract research organisations (CROs) and those working in ancillary roles, such as consultants.

We ask that you provide honest accounts of your experience and opinion on the FOB/Irwin tests, as your input will be used as the basis of a publication to examine the state-of-the-art in CNS safety assessment. Information is requested on rodents (mice and rats) and large animals (dogs, minipigs and non-human primates). All data collected in this survey will be treated in strict confidence and held securely by the NC3Rs. For queries about or problems with the survey, please contact

To participate or to get more information on this important survey of the CNS safety pharmacology community, please click the link below. The survey will close on July 13.

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