2019 University of Wisconsin-Madison Distance Academy Webinar Series
Below is an online education opportunity for SPS members who want a better understanding of Cardiovascular Physiology, Pharmacology and Safety. The course is organized and conducted by the Division of Pharmacy Professional Development, School of Pharmacy, University of Wisconsin-Madison, and is taught by SPS Members!
$200 Discount for SPS members!! Use code provided in your email at checkout (membership status is verified by SPS Headquarters)
Standard registration: $1,050
SPS Member registration: $850
Group registrations: $850 each for 2 or more from same company
Cardiovascular Physiology, Pharmacology and Safety: A Practical Review
April 3–May 29, 2019
Knowledge of the cardiovascular physiology, pharmacology, and safety is a key to moving drug projects forward. A drug development scientist must also understand cardiovascular receptor pharmacology. This course will provide pharmacological strategies for management and correction of cardiovascular diseases. You will also learn safety issues associated with the cardiovascular system. At the end of this course, you will have a cardiovascular system “toolbox” at your disposal. This will help you make smart decisions based on proven science and avoid common pitfalls.
This course is part of the Applied Drug Development Certificate. It fulfills one elective. You may take the course as is or as part of the certificate.
The purpose of this course is to provide the learner with a basic review of the fundamental physiological processes of the cardiovascular system and pharmacological strategies for management or correction of cardiovascular diseases. It will also address safety issues associated with drugs affecting the cardiovascular system. Topics covered in this course include:
- Physiological considerations associated with the cardiovascular system including autonomic nervous system, renal and respiratory systems
- Fluid compartments and their regulation; distribution of fluid volumes
- Electrical conduction of the heart (ion channel function and cardiac arrhythmias)
- Cardiac muscle function
- Cardiovascular system function - flow, blood pressure and heart rate; how blood pressure is regulated
- Cardiovascular receptor pharmacology
- Drug exposure to cardiac tissue and vascular system; PK/PD modeling; autoradiography
- Cardiovascular diseases: hypertension, congestive heart failure, ischemia, pulmonary artery hypertension, pharmaceutical-induced dysfunction
- Pharmacological considerations in the treatment of the disease states listed above
- Cardiovascular safety consideration of the development of oncology agents, biologics, RNAi therapy, gene therapy, peptides, small molecules, vaccines, and implantation devices
- Overview of cardiovascular consideration in the drug development process from chemist to market
Upon completion of the program the learner should be able to:
- Describe the physiological regulation of the cardiovascular system and what makes it work;
- Discuss cardiovascular receptor pharmacology;
- Identify the actions of various pharmacological classes of drugs which are associated with the therapeutic management of different diseases;
- Explain the drug development of novel compounds for treatment of heart disease;
- Describe the safety assessment of non-cardiac novel compounds-bringing safe compounds to the market; and
- Apply information in the course through case studies on drug development or post market reconsiderations (eg. Vioxx, Seldane, etc)
Instructors: Kristy D. Bruse, PhD, DSP, Integrated Physiology and Pharmacology Consulting, LLC; Robert Kaiser, PhD, DABT, Principal Research Scientist at Minnesota Children's Hospital, Children's Hospitals and Clinics of Minnesota; and Hugo M. Vargas, PhD, DSP, Scientific Director, Integrated Discovery & Safety Pharmacology, Amgen, Inc
Please visit the course site for additional information.
Safety Pharmacology Society Headquarters