Join Us Online Nov. 7: Use of Reverse Translation for Early Lead Optimization–Off Target Mitigation Webinar

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Dear Colleagues,

The Safety Pharmacology Society is pleased to invite you to a webinar presentation on Thursday, November 7, 2019  at 11:00 EST, 16:00 UTC (GMT) / 17:00 CET.

Use of Reverse Translation for Early Lead Optimization – Off Target Mitigation

Presenter: Laszlo Urban, MD, PhD Preclinical Secondary Pharmacology, PCS, NIBR, Cambridge, US

Abstract:  The safety bar for medicines has been raised by regulatory authorities and became a determinant factor in successful product launch. Accordingly, the pharmaceutical industry introduced broader and earlier risk assessment for better understanding of molecular bases of toxic reactions which are often shared between drugs. Safety conscious product development requires parallel, integrated optimization of efficacy and safety. For early risk assessment a powerhouse of predictive in vitro and in silico tools have been developed which enable the inexpensive de-prioritization of chemical structures with target engagement associated with ADRs, and prevents compounds with “toxic” off-target effects entering clinical trials. Learning from clinical experience led to the development of the concept of “reverse pharmacology” and extensive PK/PD analysis, which further improved the predictive value of early risk assessment. In this presentation, we will outline and review the strategy to bring clinical aspects into the preclinical space to achieve more precise prediction and elimination of clinical ADRs.

David Wei, Director, Eurofins Pharma Discovery Services

We look forward to your participation.


button_member-registration.png Free for SPS Members


button_nonmember-registration (1).png $50.00 Fee for Nonmembers


We look forward to your participation.
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