The Safety Pharmacology Society is pleased to invite you to a webinar presentation on Thursday, March 26, 2020 at 11:00 EDT, 15:00 UTC (GMT) / 16:00 CET.
Note: This webinar was rescheduled from December 12, 2019. No action is needed if you previously registered for this event.
Title: Application of translational pharmacokinetic-pharmacodynamics (PKPD) and quantitative systems pharmacology (QSP) in cardiovascular safety pharmacology
Presenter: Prof. Piet H. van der Graaf, Certara UK and University of Leiden
Description: Despite considerable efforts in academia and pharmaceutical industry, the prediction of cardiac safety of pharmacological therapeutics remains a challenge. To date, the focus has been largely on cardiac ion-channel mediated side effects (in particular hERG-channel mediated QT prolongation) and computer models (mechanistic and empirical) have been developed to predict risk from preclinical data. Indeed, it seems reasonable to expect that in the near future such models will become accepted by regulators as in-silico substitutes for actual clinical trials. Remarkably, however, despite the fact that Guyton and co-workers published an extensive model of circulatory control nearly 5 decades ago (PMID 4334846), our ability to translate preclinical cardiovascular findings to predict subtle clinical effects on, for example, blood pressure and heart rate in a quantitative manner is lagging behind. Insufficient integration of translational pharmacokinetics and pharmacodynamics may be one of the root causes for this lack of progress. An overview will be provided of the current approaches and innovations in this area, illustrated with case studies using a range of modelling approaches, including quantitative systems pharmacology.
This webinar is hosted by the SPS Academic Outreach Committee and is free to attend to all who are interested. We look forward to your participation.