A timely start of preclinical assessment of drug abuse and dependence liability is essential to keep options open to redirect, deselect and characterize drug candidates. It's not just a matter of meeting regulatory demands and timelines but creating room for improvement and reducing late attrition.
A rat behavioral two-choice tinnitus model with resistance to non-auditory side effects is presented. Salicylic acid caused tinnitus-like effects. Intense sound caused tinnitus-like, Lidocaine non-reversible effects. By the design potential bias due to hearing impairment and hyperacusis is avoided.
Wednesday opened with an engaging Keynote Presentation by Dr. Christine Mummery from Leiden University on Cardiomyocytes from Human Pluripotent Stem Cells: The New Patient in Safety Pharmacology, Drug Discovery and Disease.
Dr. Mummery discussed and presented data on derivation of heart cells from
Over 400 attendees from across the globe are participating in the SPS Annual meeting this week.
Tuesday opened with an ECG historical talk by Dr. Marc Vos, and the Introduction to Tracks talks by Dr. Jack Reynolds and Dr. Jean-Pierre Valentin (via WebEx!) Their talks covered both the Challenges for