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Study confirms the predictability of nonclinical models to humans, and show that preclinical data together with a carefully designed and monitored SAD study may provide reliable information for an early and science-based development decision.
AZD9272 and AZD2066 show lack of NMDA antagonist psychoactive effects but do share discriminative (psychoactive) effects with MTEP, a selective mGluR5 antagonist. Data suggest a specific psychoactive effect of mGluR5 antagonists.
Two-choice operant models show resistance to non-specific side effects. Recently an auditory model was presented complementing a previously published visual disturbance model. These models show promise for specifically addressing special senses, avoiding motor and motivational bias
"Much of research pharmacology is about discovering new receptors, new endogenous transmitters and mediators, new pathways, and new mechanisms, and applying this knowledge to discover and develop new therapies for old diseases. However, pharmacology does have a dark side: safety pharmacology"